Progesterone receptor modulators for endometriosis

Progesterone receptor modulators.

The review1 on ‘Progesterone receptor modulators in gynaecological practice’ in the April 2010 issue of the Journal is a valuable contribution to the available literature on a currently important subject. In the section on ‘Contraception’ the authors have dealt at length with mifepristone. Since the latter is not licensed for postcoital contraception, it would have been appreciated if the autho...

Progesterone antagonists and progesterone receptor modulators: an overview.

Since the original description of the structure of the antiprogestin, mifepristone, was published, numerous related compounds have been synthesized which may function as progesterone antagonists (PAs) or progesterone receptor modulators (PRMs). The latter are mixed agonists-antagonists. Both PAs and PRMs have therapeutic applications in female health care. Mifepristone is predominantly a PA and...

Second International Symposium Progestins, Progesterone Receptor Modulators, and Progesterone Antagonists.

Progesterone receptor modulators in gynaecological practice.

©FSRH J Fam Plann Reprod Health Care 2010: 36(2) Introduction The sex steroid progesterone plays a major role in the regulation of female reproductive activity. Circulating levels of progesterone are maximal in the secretory phase of the menstrual cycle, its main source being the corpus luteum. The effects of progesterone are mediated via the progesterone receptor (PR), which is essential not o...

Frequency of Polymorphism Alu Insertion in Progesterone Receptor Gene in Endometriosis

Background and Aims: This research aimed to study a possible link between endometriosis and polymorphism of the progesterone receptor gene. Materials and Methods: The control group consisted of 86 women without endometriosis and the case group comprised 86 patients with a diagnosis of endometriosis by laparoscopy. Genotypes for Alu insertion polymorphisms (A1/A1, A1/A2 and A2/A2) were descri...